By Drew Provan
This moment variation of the ABC of scientific Haematology is a complete and functional consultant to this extensive ranging speciality, protecting the haematological facets of such components as pathology, molecular technological know-how, melanoma, and common medication. this can be a brief quantity together with chapters on all components of haematology written through those who care for those ailments every day. The e-book presents descriptions of those illnesses and describes the pathways eager about prognosis and therapy. complete color is used all through this seriously illustrated booklet, utilizing medical fabric and textual content containers to emphasize key issues. we've additionally attempted to maintain jargon to a minimal in order that the textual content doesn't require huge previous wisdom.
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Additional info for ABC of Clinical Haematology (ABC Series)
6 Possiblr scheme for managing patients presenting with CML in chronic phase. (See Baccarani, et al. ) 25 may be offered treatment by high-dose cytoreduction (chemotherapy and radiotherapy) followed by transplantation of haemopoietic stem cells collected from the donor’s bone marrow or peripheral blood. With the typical family size in western Europe, about 30% of patients will have matched sibling donors. In selected cases, transplants may also be performed with HLA-identical unrelated donors. Allogeneic stem cell transplants are associated with an appreciable risk of morbidity and mortality, and, in general, older patients (40– 60 years) fare less well than younger patients (Fig.
Normal haemostasis The platelet membrane containss integral glycoproteins essential in the initial events of adhesion and aggregation, leading to the formation of the platelet plug during haemostasis (Fig. 1). Glycoprotein receptors react with aggregating agents, such as collagen on the damaged vascular endothelial surface and fibrinogen and von Willebrand factor (VWF), to facilitate platelet–platelet and platelet–endothelial cell adhesion. The major glycoproteins are the Ib/IX complex, the main binding protein of which is VWF, and IIb/ IIIa, which specifically binds fibrinogen.
This will usually be accompanied by thrombocytopenia, neutropenia and anaemia. In a proportion of patients, the white blood count will be normal or reduced. Coagulation Thrombocytopenia is a common cause of petechial bleeding or bruising. Disseminated intravascular coagulation (DIC) is often present in newly diagnosed patients with acute leukaemia and may result in life-threatening bleeding complications. DIC is either triggered directly by the underlying leukaemia [acute promyelocytic leukaemia (APL) is typically associated with DIC] or can be secondary to sepsis.
ABC of Clinical Haematology (ABC Series) by Drew Provan