Read e-book online Adenosine Receptors and Parkinson's Disease PDF

By Hiroshi Kase

ISBN-10: 0124004059

ISBN-13: 9780124004054

This e-book is the 1st definitive evaluation on adenosine receptor antagonists and their software to the therapy of Parkinson's ailment. The impression of those novel non-dopamine medications on vitro and in vivo structures essentially exhibits their power for the therapy of this debilitating disorder. This booklet covers how the Parkinson's disorder antagonist drug, A2A, has been researched, built, and proven. it truly is a necessary booklet for researchers drawn to the basal ganglia, purine biology, and Parkinson's sickness. Key beneficial properties* Discusses the invention and improvement of a singular non-dopaminomimetic agent for Parkinson's illness* presents the 1st definitive evaluate of adenosine antagonists and their function within the therapy of Parkinson's ailment* offers a brand new mechanism of motion of adenosine A2A receptor antagonists in motor functionProposes a speculation of adenosine A2A receptor functionality within the striatum* accomplished evaluate of adenosine, its receptor subtypes, their antagonists/agonists from biochemistry, molecular biology, medicinal chemistry, body structure, pharmacology, and neurochemistry viewpoints

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J Neurosci, 18 (1998) 1987-1995. 9. , Adenosine A1 receptor and bipolar affective disorder: systematic screening of the gene and association studies. Am J Med Genetics 81 (1998) 18-23. 10. , Tissue distribution of adenosine receptor mRNAs in the rat. BrJ Pharmacol, 118 (1996) 1461-1468. 11. , Adenosine: the brain's natural anticonvulsant? Trends in Pharmacological Sciences, 7 (1986) 128-130. 12. , Adenosine inhibits collagen and protein synthesis in cardiac fibroblasts: a role of A2B receptors.

45. , Separate promoters in the human A1 adenosine receptor gene direct the synthesis of distinct messenger RNAs that regulate receptor abundance. Mol Pharmacol, 48 (1995) 957-980. 46. , Molecular cloning and characterization of a rat Al-adenosine receptor that is widely expressed in brain and spinal cord. Mol Endocrinol, 5 (1991) 1037-1048. 47. , Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson's disease. Trends Pharmacol Sci, 18 (1997) 338- 344. 48. , and Zhou, E, Immunohistochemical detection of A1 adenosine receptors in rat brain with emphasis on localization in the hippocampal formation, cerebral cortex, cerebellum and basal ganglia.

Mol Endocrinol, 6 (1992) 384-393. 59. , The A2B adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia. J Biol Chem, 270 (1995) 2387-2394. 60. , Evidence for physiologically active axonal adenosine receptors in the rat corpus callosum. Brain Res, 784 (1998) 188-198. 61. , Molecular cloning and characterization of a human brain A1 adenosine receptor cDNA. Mol Brain Res, 16 (1992) 365-370. 62. Walker, B. , Boone, R. H. , and Jacobson, M. , Adenosine A2A receptor activation delays apoptosis in human neutrophils.

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Adenosine Receptors and Parkinson's Disease by Hiroshi Kase

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