By Frederick W. Alt
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Extra info for AID for Immunoglobulin Diversity
As expected, all of the WXXF motif mutants of UNG retained U removal activity, although some of them showed reduced activity and that could be attributed to differing 28 M A S A M I C H I M U R A M AT S U E T A L . stabilities of individual mutants. Complete loss of CSR function by WXXF site mutation clearly indicates that this site is a critical protein–protein interaction region of UNG that is essential to CSR. , 2006). Overexpression of Vpr drastically decreased IgA class switching in stimulated CH12F3‐2 cells.
DISCOVERY AND FUNCTION OF AID 21 problem with the system. When APOBEC1, a bona fide RNA editing enzyme, is overexpressed in E. , 2002). , 2004), the ability to make valid comparisons between the E. coli system and actual CSR and SHM in B cells is severely limited. Direct DNA deamination by AID has been further examined biochemically. , 2004). , 2004). Thus, both AID and APOBEC1 clearly can deaminate C in single‐stranded DNA, but the physiological relevance of these observations should be carefully considered.
Petersen‐Mahrt, S. , and Neuberger, M. S. (2005). Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases. Mol. Biol. Evol. 22, 367–377. , and Neuberger, M. S. (2002). Altering the pathway of immunoglobulin hypermutation by inhibiting uracil‐DNA glycosylase. Nature 419, 43–48. Di Noia, J. , and Neuberger, M. S. (2004). Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID‐mediated deoxycytidine deamination.
AID for Immunoglobulin Diversity by Frederick W. Alt