Download PDF by Frederick W. Alt: AID for Immunoglobulin Diversity

By Frederick W. Alt

ISBN-10: 0123737060

ISBN-13: 9780123737069

Advances in Immunology, an extended verified and hugely revered serial, provides present advancements in addition to entire stories in immunology. Articles deal with the wide variety of subject matters that contain immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and medical modalities. Edited and authored via the main scientists within the box, every one quantity presents up to date details and instructions for destiny examine.

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As expected, all of the WXXF motif mutants of UNG retained U removal activity, although some of them showed reduced activity and that could be attributed to differing 28 M A S A M I C H I M U R A M AT S U E T A L . stabilities of individual mutants. Complete loss of CSR function by WXXF site mutation clearly indicates that this site is a critical protein–protein interaction region of UNG that is essential to CSR. , 2006). Overexpression of Vpr drastically decreased IgA class switching in stimulated CH12F3‐2 cells.

DISCOVERY AND FUNCTION OF AID 21 problem with the system. When APOBEC1, a bona fide RNA editing enzyme, is overexpressed in E. , 2002). , 2004), the ability to make valid comparisons between the E. coli system and actual CSR and SHM in B cells is severely limited. Direct DNA deamination by AID has been further examined biochemically. , 2004). , 2004). Thus, both AID and APOBEC1 clearly can deaminate C in single‐stranded DNA, but the physiological relevance of these observations should be carefully considered.

Petersen‐Mahrt, S. , and Neuberger, M. S. (2005). Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases. Mol. Biol. Evol. 22, 367–377. , and Neuberger, M. S. (2002). Altering the pathway of immunoglobulin hypermutation by inhibiting uracil‐DNA glycosylase. Nature 419, 43–48. Di Noia, J. , and Neuberger, M. S. (2004). Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID‐mediated deoxycytidine deamination.

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AID for Immunoglobulin Diversity by Frederick W. Alt

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