AIDS-Associated Viral Carcinogenesis by C. Meyers PDF

By C. Meyers

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FEATURES OF PEL PEL is a distinct, high grade B-cell NHL characterized by pleural effusion, pericardial effusion, and/or ascites, generally in an HIV-infected individual, but has been described in elderly individuals with chronic heart or liver disease. 271 TREATMENT OF PEL Simonelli and colleagues,272 in a retrospective study with 277 patients with HIV infection and systemic lymphoma, had 11 individuals in the group that were classified in the PEL category. Eight of the 11 patients received CHOP-like regimen and CR was reached in 42% of the patients, with a median survival of 6 months.

Median event-free survival, approximately a year, was similar between both groups. 027). Up to 60% of deaths were in patients with a CD4 count of <50/mm3, and 40% occurred during the maintenance phase of rituximab. 101–104 More recently, several authors have reported on small series of patients treated at individual institutions for high-first risk remission, relapsed, or refractory ARL. No definitive conclusions regarding efficacy can be made due to the small and varied group of patients. 79 All studies except the French series by Diez-Martin108 and colleagues have required HIV disease to be under control for HCT, either by low to undetectable HIV viral loads or CD4 counts >100/mm3.

195–197 Paclitaxel has also been recently used as a cytotoxic agent against KS. 202,203 Interferon For HIV-infected individuals who have appropriate immune reconstitution with antiretrovirals, but still have disseminated cutaneous KS, interferon-alpha may be a favorable option. 168 Adverse side effects from interferon-alpha encompass fever, chills, neutropenia, hepatotoxicity, and cognitive impairment. Anti-HHV-8 Therapy The discovery of HHV-8 in all forms of KS has raised the possibility of using antiviral agents to target this virus.

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AIDS-Associated Viral Carcinogenesis by C. Meyers


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