By Wojciech Gorczyca
This broad reference masking neoplastic hematopathology contains over 500 color illustrations depicting hematopoietic tumors related to lymph nodes, spleen, bone marrow, and more often than not affected extranodal organs, with unique emphasis at the differential prognosis. It discusses simple medical, prognostic, morphologic and phenotypic information, with various tables summarizing the phenotypic profiles of the most typical hematologic tumors. an important function of this e-book is an method of hematologic tumors in accordance with the WHO category, with appropriate examples and emphasis at the most beneficial morphologic and immunophenotypic good points utilized in diagnosis.It may be a useful reference for all working towards hematologists, oncologists and pathologists.
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Extra info for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
4 presents the frequency of major B-cell lymphoproliferative disorders with aberrant phenotype. Identification of abnormal T-cells by f low cytometry (FC) An abnormal T-cell population may be identified by FC based on loss or diminished expression of one or more of the pan-T antigens (CD2, CD3, CD5, CD7), aberrant expression of CD4/CD8 (subset restriction, dual positive expression or lack of both markers), loss of expression of CD45, increased forward scatter, aberrant expression of TCR (dim expression of TCR alpha/beta, positive expression of TCR gamma/delta or lack of both TCR), and expression of additional markers, such as CD30, B-cell antigens (CD19, CD20), NK-cell markers (CD16, CD56, CD57), pan-myeloid antigens (CD13, CD33), CD117 and CD1020,22,41.
Lymphoma/leukemia, precursor T-cell neoplasms do not show loss of CD45. Dim expression of TCRαβ, lack of both TCR-associated antigens or positive expression of TCRγδ, on a significant proportion of T-cells indicates a malignant process. Of the additional (non-T-cell-associated) antigens useful in the diagnosis of T-cell lymphoproliferations, the most commonly applied are CD30, CD16, CD56, CD57, CD117 and CD10. CD30 is expressed by anaplastic large cell lymphoma and a subset of other T-cell disorders, including peripheral T-cell lymphoma, and unspecified and enteropathy-type T-cell lymphoma.
Plasma cells secrete their immunoglobulin antibodies from their cytoplasm into the serum, thereby enabling the infection or intruder proteins to be eliminated. Programmed cell death (apoptosis), as well as suppressor T-cells, prevents the clonal cells from becoming autonomous, immortal and hence neoplastic. Spleen Spleen has a tripartite role, (i) acting as a sieve for the circulatory system (similar to that of lymph node for the lymphatic system), (ii) phagocytosis (elimination of senescent red blood cells, bacteria and other foreign material) and (iii) storing blood cell elements for possible future use.
An Atlas of Differential Diagnosis in Neoplastic Hematopathology by Wojciech Gorczyca