By G.O. Evans
Hematology info from in vivo toxicology reports continues to be one among the main predictive measures for human possibility, because the similar measurements made in pre-clinical toxicology stories should be made in early scientific trials.
Covering the 3 major blood mobilephone forms – erythrocytes, leukocytes and thrombocytes, this paintings is designed to explain issues for brand spanking new entrants to the fields of laboratory animal hematology and toxicology, specially these issues the place the principles for human hematology don't consistently practice. a whole bankruptcy is dedicated to immunotoxicology, a systematic self-discipline that's heavily aligned with hematology.
The textual content additionally addresses pre-analytical and analytical variables that impact animal reviews, as those play a much more vital half whilst reading information not like people the place lots of those variables may be good managed or have much less physiological impact. details has been collated from released papers, textbooks and unpublished facts: Readers are supplied with key references to motivate additional examine
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Additional info for Animal Hematotoxicology: A Practical Guide for Toxicologists and Biomedical Researchers
2003. Iron deficiency and erythropoiesis: New diagnostic approaches. Clin. Chem. 49:1573–78. Collingwood, N. , and Evans, G. O. 1995.
Haig, D. M. 1992. Haemopoietic stem cells and the development of the blood cell repertoire. J. Comp. Pathol. 106:121–36. Irons, E. , ed. 1985. Toxicology of the blood and bone marrow. New York: Raven Press. Lajtha, L. G. 1970. Kinetics of haemopoiesis. Br. J. Radiol. 44:519. Schwarzmeier, J. D. 1996. The role of cytokines in haematopoiesis. Eur. J. Haematol. ):69–74. Testa, N. , eds. 1993. Haematopoiesis: A practical approach. Oxford: IRL Press. Weiss, L. P. 1995. The structure of hematopoietic tissues.
Plasma haptoglobin is reduced or not detectable, as increasing amounts of plasma hemoglobin are bound to the haptoglobin. The spleen weights and histopathology reveal splenomegaly and hematuria may be evident. The life span of erythrocytes in hemolytic anemias is reduced. Although radioactive isotope studies can be used to demonstrate reduced red cell life span, this is mainly of academic rather than practical use in preclinical drug development. Oxidative Hemolysis The inhibition of erythrocytic enzymes of the pentose–phosphate pathway and Embden–Meyerhof pathways can produce hemolysis with the oxidation of hemoglobin to methemoglobin, or sulfhemoglobin with or without the formation of Heinz bodies The oxidation may directly injure the cell wall by lipid peroxidation or change the hemoglobin molecule, which in some circumstances leads to its denaturation (Gordon-Smith, 1980; Edwards and Fuller, 1996).
Animal Hematotoxicology: A Practical Guide for Toxicologists and Biomedical Researchers by G.O. Evans