Ola Skold(auth.)'s Antibiotics and Antibiotic Resistance PDF

By Ola Skold(auth.)

ISBN-10: 0470438509

ISBN-13: 9780470438503

ISBN-10: 1118075609

ISBN-13: 9781118075609

This e-book, that is the translated model of a Swedish ebook, combines a basic creation of quite a few antibiotics with a better dialogue of resistance. the focal point on resistance in studying approximately antibiotics may help destiny scientists realize the matter antibiotics resistance poses for medicinal and drug-related fields, and maybe set off extra learn and discoveries to struggle antibiotic resistant traces.

present overviews of the subject are integrated, in addition to particular discussions at the person mechanisms (betalactams, glycopeptides, aminoglycosides, and so forth) utilized in a number of antibacterial brokers and causes of the way resistances to these boost. tools for counteracting resistance improvement in micro organism are mentioned as well.

Chapter 1 Antibiotics: the best Triumph of medical drugs (pages 1–19):
Chapter 2 Distribution of Antibiotics (pages 21–28):
Chapter three Sulfonamides and Trimethoprim (pages 29–68):
Chapter four Penicillins and different Betalactams (pages 69–94):
Chapter five Glycopeptides (pages 95–102):
Chapter 6 Aminoglycosides (pages 103–113):
Chapter 7 different Antibiotics Interfering with Bacterial Protein Synthesis (pages 115–131):
Chapter eight Quinolones (pages 133–145):
Chapter nine Antibacterial brokers no longer relating to the massive Antibiotic households (pages 147–166):
Chapter 10 Mechanisms for the Horizontal unfold of Antibiotic Resistance between micro organism (pages 167–186):
Chapter eleven how one can deal with Antibiotic Resistance (pages 187–202):

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Extra resources for Antibiotics and Antibiotic Resistance

Sample text

This is a further interesting illustration of the nonreversibility of resistance in the absence of the selecting effect of the drug. The drug-resistant phenotypes do not seem to be at any disadvantage in competition with their drug-susceptible relatives. Sulfonamide-resistant strains of S. pyogenes were shown to have very high resistance, some of them with MIC values of 1 mg/mL. The mechanism of resistance in S. pyogenes turned out to be related to the sulfonamide resistance of N. meningitidis, in that it is based on the horizontal transfer of genetic material.

Earlier, a large part of the antibiotics consumption was used as feed additives in husbandry and to some extent also in plant agriculture. The use in animals was based on the empirical but not completely understood observations that meat animals gained weight faster when given antibiotics in their fodder. It soon became clear, however, that this practice led to the spread of antibiotic resistance through the food chain into the general population. An example of this was the use of avoparcin, a glucopeptide, an analog to vancomycin (see Chapter 5).

In Scandinavia, the distribution of sulfonamides as a single drug for systemic use is presently nil. Aside from preparations for external use, as in ointments, the minimal distribution of sulfonamides that still occurs is in combination with trimethoprim. There are three primary reasons for the almost nonexistent use of sulfonamides. First, other and in many cases more efficient antibacterial drugs became available through the decades following the introduction of sulfonamides in 1935. Second, resistance emerged rapidly in many pathogens.

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Antibiotics and Antibiotic Resistance by Ola Skold(auth.)

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