Get Antibody Fc. Linking Adaptive and Innate Immunity PDF

By Margaret Ackerman, Falk Nimmerjahn

ISBN-10: 0123948029

ISBN-13: 9780123948021

Antibody Fc is the 1st unmarried textual content to synthesize the literature at the mechanisms underlying the dramatic variability of antibodies to steer the immune reaction. The e-book demonstrates the significance of the Fc area, together with protecting mechanisms, effector mobile kinds, genetic information, and variability in Fc area functionality. This quantity is a serious single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers in addition to graduate scholars in immunology and vaccinology.

Antibodies signify the correlate of safety for varied vaccines and are the main swiftly growing to be type of gear, with purposes starting from melanoma and infectious affliction to autoimmunity. Researchers have lengthy understood the variable area of antibodies, that are chargeable for antigen reputation, and will offer security by means of blocking off the functionality in their goal antigen. notwithstanding, fresh advancements in our realizing of the security mediated through antibodies have highlighted the serious nature of the antibody consistent, or Fc area, within the organic job of antibodies. The Fc area permits antibodies to hyperlink the adaptive and innate immune structures, offering specificity to quite a lot of innate effector cells. furthermore, they supply a suggestions loop to control the nature of the immune reaction through interactions with B cells and antigen-presenting cells.

  • Clarifies the several mechanisms of IgG job on the point of different version platforms used, together with human genetic, mouse, and in vitro
  • Covers the function of antibodies in melanoma, infectious ailment, and autoimmunity and within the atmosphere of monoclonal antibody remedy in addition to obviously raised antibodies
  • Color illustrations improve motives of the immune system

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Additional info for Antibody Fc. Linking Adaptive and Innate Immunity

Example text

Venkateswarlu K, Cullen PJ. Signalling via ADPribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase. Biochem J 2000;345(Pt 3):719–24. Liao F, Shin HS, Rhee SG. Tyrosine phosphorylation of phospholipase C-γ 1 induced by crosslinking of the high-affinity or low-affinity Fc receptor for IgG in U937 cells. Proc Nat Acad Sci USA 1992;89(8):3659–63. Zheleznyak A, Brown EJ. Immunoglobulin-mediated phagocytosis by human monocytes requires ANTIBODY Fc REFERENCES protein kinase C activation.

SHIP modulates immune receptor responses by regulating membrane association of Btk. Immunity 1998;8(4):509–16. Baerenwaldt A, Lux A, Danzer H, Spriewald BM, Ullrich E, Heidkamp G, et al. Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo. Proc Nat Acad Sci USA 2011;108(46):18772–7. Hazeki K, Inoue K, Nigorikawa K, Hazeki O. Negative regulation of class IA phosphoinositide 3-kinase by protein kinase Cδ limits Fcγ receptormediated phagocytosis in macrophages.

Biochem Biophys Res Commun 2000;276(2):472–6. Larsen EC, DiGennaro JA, Saito N, Mehta S, Loegering DJ, Mazurkiewicz JE, et al. 7 cells. J Immunol 2000;165(5):2809–17. Anderson CL, Guyre PM, Whitin JC, Ryan DH, Looney RJ, Fanger MW. Monoclonal antibodies to Fc receptors for IgG on human mononuclear phagocytes. Antibody characterization and induction of superoxide production in a monocyte cell line. J Biol Chem 1986;261(27):12856–64. Pfefferkorn LC, Fanger MW. Cross-linking of the high affinity Fc receptor for human immunoglobulin G1 triggers transient activation of NADPH oxidase activity.

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Antibody Fc. Linking Adaptive and Innate Immunity by Margaret Ackerman, Falk Nimmerjahn


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