By Pier Luigi Meroni
This publication, a part of the sequence infrequent ailments of the Immune procedure, bargains finished, updated insurance of the pathophysiology and administration of the antiphospholipid syndrome (APS). Immunologic and genetic elements are mentioned and the pathogenic mechanisms accountable for such phenomena as APS-mediated thrombosis and being pregnant loss/complications are defined. the most medical manifestations, category standards and diagnostic instruments are pointed out, and shut consciousness is paid to the character of the involvement of varied organs or organ platforms in APS. particular chapters describe the remedy of the various signs, treatments of price in heading off recurrences, and leading edge remedy techniques. The authors are senior specialists within the box who're aided by means of more youthful fellows, making sure that the ebook can be educationally orientated. this useful quantity might be a worthwhile software for postgraduates in education and execs wishing to increase their wisdom of this particular syndrome.
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Extra resources for Antiphospholipid Antibody Syndrome: From Bench to Bedside
Results should be expressed as follows: dRVVT Screen Ratio = Patient dRVVT Screen results ( in seconds ) PNP dRVVT Screen ( in seconds ) Perform testing on patient plasmas mixed with the pooled normal plasma (PNP) at 1:1 proportion and express results as follows: dRVVT mixing Ratio = Patient dRVVT mixing (1 : 1) PNP dRVVT ( in seconds ) Confirmatory Test: Results are confirmatory of LA if the % correction of patient’s plasma at low (screen) and high (confirm) phospholipid concentration is above the local cutoff value.
Ioannou Y et al (2007) Binding of antiphospholipid antibodies to discontinuous epitopes on domain I of human beta(2)-glycoprotein I: mutation studies including residues R39 to R43. Arthritis Rheum 56:280–290 16. De Laat B et al (2006) Pathogenic anti-beta2 glycoprotein I antibodies recognize domain I of beta-2 glycoprotein I only after a conformational change. Blood 107:1916–1924 3 Antiphospholipid Antibody Mechanisms of Thrombosis 35 17. De Laat B et al (2011) Immune responses against domain I of β2-glycoprotein I are driven by conformational changes: domain I of β2-glycoprotein I harbors a cryptic immunogenic epitope.
5 aPL and Inflammation-Mediated Damage Acute inflammatory events can be responsible for a negative pregnancy outcome via the activity of proinflammatory mediators, such as complement, tumor necrosis factor-α [TNF-α], and chemokines that have been shown to have a role in animal models of aPL-induced fetal loss [3, 4, 19, 20]. Evidence from experimental animal models confirmed the ability of human IgG with aPL activity, passively infused after implantation (10 mg/mouse per injection), to induce fetal resorption and growth retardation.
Antiphospholipid Antibody Syndrome: From Bench to Bedside by Pier Luigi Meroni