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By P. Sansonetti

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These granules carry 85% of the cellular NADPH oxidase content which is crucial for antimicrobial activity. Lactoferrin and NGAL are bacteriostatic because they chelate iron. Lactoferrin is often used as a marker for this type of granule. hCAP-18 is cleaved, extracellularly or inside the phagosome, by PR-3 (present in azurophil granules). This cleavage releases the C-terminus fragment LL-37 which has antimicrobial activity against Gram-negative and -positive bacteria. Finally, lysozyme cleaves peptidoglycan, an essential cell wall component of almost all bacteria.

2006) Genomic changes during chronic Helicobacter pylori infection. J. , 188, 249–254. I. (2006) The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression. Proc. Natl. Acad. Sci. USA, 103, 9999–10004. 1 Introduction Around 1870, Paul Ehrlich developed staining techniques to study blood and bone marrow. He first established that blood cells showed affinities for alkaline, acidic and neutral dyes, discriminating between three kinds of granulated white blood cells: normoblasts, megaloblasts and leukemic cells.

2004) Increased frequency of genomic alterations in Staphylococcus aureus during chronic infection is in part due to phage mobilization. J. Infect. , 189, 724–734. , and Lory, S. (2008) Dynamics of Pseudomonas aeruginosa genome evolution. Proc. Natl. Acad. Sci. USA, 105, 3100–3105. , and Suerbaum, S. (2001) Recombination and mutation during long-term gastric colonization by Helicobacter pylori: estimates of clock rates, recombination size, and minimal age. Proc. Natl. Acad. Sci. USA, 98, 15056–15061.

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Bacterial Virulence by P. Sansonetti


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