Read e-book online Basic Immunology: Functions and Disorders of the Immune PDF

By Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD

ISBN-10: 1455707074

ISBN-13: 9781455707072

Understand all of the crucial recommendations in immunology with Basic Immunology: services and problems of the Immune System! This concise, centred textual content provide you with an up-to-date, obtainable creation to the workings of the human immune method.

  • Efficiently grasp the immunology info you wish through clinically centred content material, logically geared up through mechanism.
  • Apply what you will have realized to real-world events by referencing the appendix of scientific situations.
  • Enhance your learning with assistance from a variety of full-color illustrations and precious tables, in addition to precis containers, evaluation questions, and a thesaurus of immunology terms.
  • Study immunology anywhere! on-line entry to www.StudentConsult.com opens the door to an improved publication and ancillary components!

  • Visualize advanced immunology recommendations with a very up-to-date paintings program.
  • Test your knowledge. New PowerPoint evaluate slides additional to www.StudentConsult.com are perfect for learn sessions.

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Additional resources for Basic Immunology: Functions and Disorders of the Immune System, 4e

Example text

The two principal types of reactions of the innate immune system are inflammation and antiviral defense. Inflammation consists of the accumulation and activation of leukocytes and plasma proteins at sites of infection or tissue injury. These cells and proteins act together to kill mainly extracellular microbes and to eliminate damaged tissues. Innate immune defense against intracellular viruses is mediated mainly by natural killer (NK) cells, which kill virus-infected cells, and by cytokines called type I interferons, which block viral replication within host cells.

Neutrophils, also called polymorphonuclear leukocytes (PMNs), are the most abundant leukocytes in the blood, numbering 4000 to 10,000 per milliliter (Fig. 2–7, A). In response to infections, the production of neutrophils from the bone marrow increases rapidly, and their number may rise to 20,000 per mL of blood. The production of neutrophils is stimulated by cytokines, known as colonystimulating factors (CSFs), which are secreted by many cell types in response to infections and act on hematopoietic stem cells to stimulate proliferation and maturation of neutrophil precursors.

Ds, Double-stranded; LPS, lipopolysaccharide; ss, single-stranded. cytosolic complex of NLRP-3 (the sensor), an adaptor, and caspase-1 is known as the inflammasome. The inflammasome is important not only for host defense but also because of its role in several diseases. Gain-of-function mutations in the sensor components of the inflammasome are the cause of rare but severe diseases, called autoinflammatory syndromes, characterized by uncontrolled and spontaneous inflammation. IL-1 antagonists are effective treatments for these diseases.

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Basic Immunology: Functions and Disorders of the Immune System, 4e by Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD


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