By Ann M. Dvorak
Basophils and mast cells are comparable yet designated secretory cells with a well-documented position in immediate-hypersensitivity reactions. The presence of those cells in quite a few mobilephone mediated hypersensitive reaction reactions, in tissues of a number of ailments, and as an element of the host response to damage and service in several conditions is celebrated. liberate of kept and newly generated mediators of irritation from basophils and mast cells contributes to the cascade of pathogenetic occasions in situations below which those liberate reactions take place. regardless of insights received via reviews of those pathologic occasions, the position of basophils and mast cells and their secretory items in future health isn't recognized. during this ebook, I overview a lot of the structural information about basophils and mast cells of a number of species. Ultrastructural experiences of rat mast cells traditionally precede and quantitatively exceed related reports of basophils and mast cells of alternative species. for that reason, I first evaluate those historical past experiences as an entity. Then I talk about the contents of 2 popular organelles-granules and lipid bodies-in basophils and mast cells of numerous species. The ultrastructural morphology of basophils and mast cells in 3 species is gifted intimately to set up acceptable guidance for his or her popularity and to supply common ideas for research that are acceptable for the identity of those cells in different species as well.
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Extra resources for Basophil and Mast Cell Degranulation and Recovery
M. Dvorak et al. , 1972a, 1980b, 1985c,d; Dvorak and Dvorak, 1975) (see Chapter 5, Section 5. 2. 1. 2) was documented for basophils of both species (Figures 17-19). This suggests that a major function of basophils may be to internalize exogenous peroxidatic materials and store them in granules. Charcot-Leyden crystals (CLC) were initially described in association with human eosinophils in patients with myelogenous leukemia and asthma (Charcot and Robin, 1853; Leyden, 1872). These hexagonal , bipyramidal crystals have generally been associated with eosinophilic diseases and were thought to be unique to eosinophils.
In mast cells not stimulated to degranulate by compound 48/80, cationized ferritin entered the cell in endocytic structures, some of which traveled to the Go1gi area by 6 hr. , 1981b). In mast cells stimulated with compound 48/80, cationized ferritin was present in small vesicles beginning between 1 and 2 hr and in condensing vacuoles in the Golgi area by 2 hr. After 6-8 hr of incubation, large amounts of cationized ferritin were found within central cytoplasmic cavities, formed by fusion of exocytotic cavities.
1980d, 1988a). CLC are generally present in body fluids and tissues within which large numbers of eosinophils reside. , 1982) but not to human mast cells (Leiferman et al. , 1986). , 1980), to distinct membrane-bound coreless primary granules in mature eosinophils (A. M. , 1988a). Immunogold studies of similar design have localized CLC protein to granules and to intragranular crystals present in mature, activated human basophils (Figure 21) (A. M . Dvorak and Ackerman, 1989). 44 Chapter 3 FIGURE 20.
Basophil and Mast Cell Degranulation and Recovery by Ann M. Dvorak